Product Description
Silver Alginate Dressing is a non-woven pad composed of calcium alginate and silver particles. The silver content is 50µg/100 cm2. The silver particles are in the form of encapsulated metallic silver, which is very stable and won't be oxidized even on exposure to light.
LUOFUCON® Silver Alginate Dressing is proved to have broad spectrum antibacterial effect , based on in vitro laboratory testing.
1. Silver Release
Figure1 shows that Silver Alginate Dressing leaches about 57% of the total silver during the first 24 hours, and 30%, 24% of its total silver during 24-48, 48-72 hours, respectively.
The release profiles indicates that the release of silver from the dressing is well controlled.
Note:
Two pieces of the dressing in the size of 10 x 10 cm were used in this test. The test was performed by China National Analytical Center at Guangzhou.
2. Antibacterial Activity
2.1 Comparative Test
One representative Gram-positive bacteria(Staphylococcus aureus) and one representative Gram-negative bacteria(Pseudomonas aeruginosa) were tested under AATCC 100-2004.
Figure 2 and Figure 3 show Silver Alginate Dressing has four log reduction (99.99%)for both organisms, the other two products only have three log reduction (99.9%).
Figure 2 Log Reduction - Staphylococcus aureus Figure 3 Log Reduction - Pseudomonas aeruginosa
Note: Comparison 1 and 2 are other silver alginate dressings in the market. The test was performed by our own laboratory.
2.2 Antibacterial Effectiveness Test
AATCC 100-2004 only specifies the use of one Gram-positive and one Gram-negative bacteria. However, we tested six clinical-relevant bacteria ( 3 Gram-positive and 3 Gram-negative bacteria) for the evaluation of antibacterial effectiveness.
Test Organism |
Test Method |
| Enterococcus faecalis |
ATCC 29219 |
Dressing specimens and controls were tested under simulated use conditions for seven days. During this time, test articles were kept moistened daily with phosphate buffered water containing 10% Fetal Bovine Serum to simulate daily use. The antibacterial activity testing was performed with an inoculum challenge of more than 106 CFU total. |
| Escherichia coli |
ATCC 8739 |
| Klebsiella pneumoniae |
ATCC 4352 |
| Pseudomonas aeruginosa |
ATCC 9027 |
| Staphylococcus aureus |
ATCC 6538 |
| Streptococcus pyogenes |
ATCC 19615 |
Figure 4 Antibacterial Effectiveness(GLP Study)
At day-1, results show LUOFUCON® Silver Alginate Dressing has bacteria reduction of at least four log reduction for all six test organisms;
At day-7, bacteria reduction for all the organisms is at least two log reduction(data in table 1 and table 2).
Note:The test was performed under Good Laboratory Practice regulations, by WuXi AppTec, Inc.(Address :1265 Kennestone Circle, Marietta, GA 30066).
Based on the test results, LUOFUCON® Silver Alginate Dressing has broad spectrum antibacterial effect for Gram-positive and Gram-negative bacteria.
Table 1: 1 Day Antibacterial Effectiveness
|
1 Day |
|
Replicate 1 |
Replicate 2 |
Replicate 3 |
| Staphylococcus aureus |
>4.0 |
>4.1 |
>4.1 |
| Streptococcus pyogenes |
>4.4 |
>4.4 |
>4.3 |
| Enterococcus faecalis |
>4.3 |
>4.2 |
>4.3 |
| Escherichia coli |
>4.2 |
>4.2 |
>4.13 |
| Klebsiella pneumoniae |
>4.1 |
>4.0 |
>4.1 |
| Pseudomonas aeruginosa |
>4.1 |
>4.1 |
>4.1 |
Table 2: 7 Days Antibacterial Effectiveness
|
7 Day |
|
Replicate 1 |
Replicate 2 |
Replicate 3 |
| Staphylococcus aureus |
>4.0 |
>4.0 |
>4.0 |
| Streptococcus pyogenes |
>4.1 |
>4.1 |
>4.1 |
| Enterococcus faecalis |
2.1 |
1.6 |
2.6 |
| Escherichia coli |
>4.3 |
>4.3 |
>4.3 |
| Klebsiella pneumoniae |
>4.2 |
>4.2 |
>4.2 |
| Pseudomonas aeruginosa |
>4.0 |
>4.0 |
>4.0 |
Shelf life
3 years
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